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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Regulatory macrophages ： ウィキペディア英語版 Regulatory macrophages Regulatory macrophages (Mregs) represent one of basic macrophage population according fundamental macrophage function. These functions are host defense (classically activated macrophages), wound healing (alternatively activated/wound-healing macrophages) and immune regulation (Mregs). Physiological role of Mregs is to dampen the immune response and limit immunopathology. Unlike classically activated macrophages, Mregs produce high levels of anti-inflammatory cytokine interleukin 10 (IL-10) and turn off IL-12 synthesis. And unlike wound-healing macrophages, Mregs do not induct arginase, so they do not contribute to the production of the extracellular matrix. ==Mreg origin== Mregs can arise following innate or adaptive immune responses. Mreg population was firstly described after FcγR ligation by IgG complexes in occurrence of pathogen-associated molecular patterns (e. g. lipopolysaccharide or lipoteichoic acid) acting through Toll-like receptors. This stimulation specifically decreased IL-12 production and increased IL-10 production. Coculuration of macrophages and regulatory T cells (Tregs) elicited differentiation of macrophages toward Mregs. Similar effect provoked interaction of macrophages and B-1 B cells. Mregs can even arise following stress responses. Activation of the hypothalamic-pituitary-adrenal axis leads to production of glucocorticoids that cause decreased production of IL-12 by macrophages. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Regulatory macrophages」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.